Nasal light therapy photobiomodulation therapy device

What is PBM Photobiomodulation?

Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most worried about by humankind in general, is the brain.

The brain suffers from many different disorders that can be classified into three broad groupings: traumatic events (stroke, traumatic brain injury, and global ischemia), degenerative diseases (dementia, Alzheimer's and Parkinson's), and psychiatric disorders (depression, anxiety, post traumatic stress disorder). There is some evidence that all these seemingly diverse conditions can be beneficially affected by applying light to the head. There is even the possibility that PBM could be used for cognitive enhancement in normal healthy people. In this transcranial PBM (tPBM) application, near-infrared (NIR) light is often applied to the forehead because of the better penetration.

Principle:

Cytochrome C oxidase (CCO, also known as complex IV) is a specific structure in mitochondria that ACTS as a photon receptor and thus plays the PBM effect.PBM prevents respiratory inhibition (and correspondingly reduces energy storage) in stress cells by isolating nitric oxide (NO) and reversing the shift of oxygen in cytochrome C oxidase.This triggers transcription factors that alter gene expression levels.The binding of nitric oxide (NO) to copper (or heme) centers in the mitochondrial cytochrome C oxidase (CCO) inhibits cell respiration.But cytochrome C oxidase, which absorbs red or near-infrared (NIR) light, dissociates nitric oxide, restoring oxygen, increasing cellular respiration, and forming adenosine triphosphate (ATP).This triggers a cascade of intracellular reactions involving nitric oxide, reactive oxygen species (ROS), and cyclic adenosine phosphate (cAMP) that produce beneficial effects of PBM. 

Main Functions:

• NIR light can penetrate through the skull and reach the brain tissue.
• NIR is absorbed by cytochrome c oxidase in mitochondria.
• Heat-gated ion channels also play a role.
• Increase blood flow, active oxygen, ATP, neuroprotection, less inflammation, brain repair.
• Make treatment on traumatic, neurodegenerative and psychiatric diseases.

Experiment We Do

One of the experiments cooperate with the Complementary and Integrative Laser Medicine, Biomedical Engineering in Anesthesia and Intensive Care Medicine, Medical University.
Showed a clear response of cerebral rSO2 in relation to the our PBM helmet stimulation. 
December, 2018

One of the experiments cooperate with the German Healthcare field organization

Showed a clear response of NADH reduction, which means the increasing of ATP in relation to our PBM helmet stimulation.

May, 2019

One of the experiments conducted by Italy brain health organization
29 Italian patients underwent NIR stimulation therapy for 1-month, tested before and after and shown good results 

March, 2020

Many reports and datas, if you want more details, welcome to contact me.